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Significance of Zinc Metabolism in Blood Granulocytes in Surgical Cancer Patients

The bulletin of the Yamaguchi Medical School Volume 16 Issue 2-4 Page 173-182
published_at 1969-12
A020016000208.pdf
[fulltext] 914 KB
Title
Significance of Zinc Metabolism in Blood Granulocytes in Surgical Cancer Patients
Creators Fuchimoto Takeshi
Creators Takashima Masanari
Creators Fujii Masataka
Creators Santoki Yoshiro
Creators Shirozu Hideharu
Creators Santoki Osamu
Source Identifiers
 Significance of zinc metabolism in blood granulocytes was studied in surgical cancer patients. The zinc content of blood granulocytes was analyzed using the histochemical method of McNary and the score method of Szmigielski and Litwin. The zinc score in preoperative cancer patients was markedly lower than that in non-cancer patients. This low values were not observed in most of early carcinomas while the score was almost always lowered in non-resectable carcinomas. This suggests that zinc metabolism in blood granulocytes is not disturbed until cancer progresses beyond a certain extent. The low score in preoperative cancer patients was elevated to normal values 3 to 5 weeks after the curative operation with or without cancer chemotherapy. In non-resectable carcinomas, changes in the zinc score following cancer chemotherapy seemed to run parallel with its effectiveness. These observations indicate that there is a close relation between the zinc content of blood granulocytes and the progress of cancer. This histochemical method is useful as a clinical routine method to examine the progress of cancer.
Subjects
医学 ( Other)
Languages eng
Resource Type departmental bulletin paper
Publishers Yamaguchi University Graduate School of Medicine
Date Issued 1969-12
File Version Version of Record
Access Rights open access
Relations
[ISSN]0513-1812
[NCID]AA00594272
Schools 医学部