An invited review following the Soujinkai Award : tissue-specific expression of estrogen receptor1 is regulated by DNA methylation in a T-DMR
The bulletin of the Yamaguchi Medical School Volume 64 Issue 3-4
Page 13-19
published_at 2017
Title
An invited review following the Soujinkai Award : tissue-specific expression of estrogen receptor1 is regulated by DNA methylation in a T-DMR
Source Identifiers
Creator Keywords
estrogen receptor 1 (ESR1)
tissue-specific expression
DNA methylation
tissue-dependent and differentially methylated region
breast cancer
ESR1 expression was tissue-specific, being high in the endometrium and mammary gland and low/nil in the placenta and skin.A long-standing question was how this tissue-specific expression of ESR1 was regulated. In other genes, DNA methylation of a region called the T-DMR (tissue-dependent and differentially methylated region) has been associated with tissue-specific gene expression.We recently found that human ESR1 has a T-DMR and DNA methylation of the T-DMR, but not the promoter region, regulates its tissue-specific expression. Furthermore, we revealed that EGR1 is a possible transcription factor to bind the T-DMR and upregulate ESR1 expression under DNA hypomethylation of the T-DMR.
Languages
eng
Resource Type
departmental bulletin paper
Publishers
Yamaguchi University School of Medicine
Date Issued
2017
File Version
Version of Record
Access Rights
open access
Relations
[ISSN]0513-1812
[NCID]AA00594272