Syntheses of 2-Formyl-, 2,3-Diformyl- and 8-Formyl-1-azaazulenes

Syntheses of 2-Formyl-, 2,3-Diformyl- and 8-Formyl-1-azaazulenes

Creators Koizumi Kazuya

Creators Miyake Chikara

Creators Ariyoshi Tomoyuki

Creators Umeda Kenji

Creators Yamauchi Noriko

Creators Tagashira Shoji

Creators Murakami Yoshiko

Creators Fujii Hiroyuki

Creators Abe Noritaka

2-Styryl-1-azaazulenes were synthesized by two ways: a) Suzuki coupling of 2-bromo-1-azaazulenes with trans-2-phenylvinylboronic acid b) Condensation of 2-methyl-1-azaazulen, being synthesized by Negishi coupling of 2-bromo-1-azaazulene with dimethylzinc, with benzaldehyde. Oxidative cleavage of 2-styryl-1-azaazulenes with OsIO_4-KIO_4 gave 2-formyl-1-azaazulenes. 8-Formyl-1-azaazulenes were synthesized by the reaction of 1-azaazulenes with 2-lithio-1,3-dithiane followed by the hydrolysis.

[ISSN]0385-5414

[NCID]AA00663739