Observation on the Electrical and Mechanical Activities of the Money Ileum in Relation to Drug Actions

Observation on the Electrical and Mechanical Activities of the Money Ileum in Relation to Drug Actions

Creators Ohkawa Hiromichi

Creators Watanabe Masao

Electrical and mechanical activities of monkey ileum were recorded simultaneously. Spontaneous, rhythmic slow wavws which have a duration of seconds and a relatively uniform amplitude within a singlepreparation were obtained. Spikes were superimposed on each slow wave and the spike activity was well synchronized with a phasic contaction. Acetylcholine potentiated the mechanical activity and atropine blocked the response to acetylcholine. Noradrenaline inhibited the spike and mechanical activities and alpha- and beta-blockers depressed the inhibitory action of noradrenalin. APT, AMP and cycric AMP produced the inhibitory action on the mechanical actibity. 5-HT rised the contactile activity. The results of this study indicate that the electrical activity of the longitudinal muscle of the monkey ileum was simlar to those obtained from the intestinal muscle of rodentia and carnivora. Evidences for the presence of both type receptors were available.

[ISSN]0513-1812

[NCID]AA00594272