血液悪性疾患に対する自家造血幹細胞移植 : 当科における治療成績と文献的考察

Autologous Hematopoietic Stem Cell Transplantation in Hematological Malignancies: Results of Our Institution and Review of the Llteratures

Creators Yamada Tetsuya

Creators Katsuki Kensaku

Creators Takeda Komei

Creators Kameda Naoko

Creators Ariyoshi Koichi

Creators Toyosawa Keimei

Creators Ando Toshihiko

Creators Inoue Hirofumi

Creators Nomiyama Jyun

Creators Oeda Eiichi

We performed autologous hematopoietic stem cell transplantation m the patients with hematological malignancies of 12 cases of malignant lymphoma, 3 cases of acute lymphoblastic leukemia, 2 cases acute lymphoblastic leukemia, 3 cases of multiple myeloma, I case of chronic myelogenous leukemia and I case of Ewing's sarcoma. The former 9 cases were autologous bone marrow transplantation, and recent cases were peripheral blood stem cell transplantation Long term surviving without relapse was obtained in 5 cases of malignant lymphoma and I case of acute myeloblastic leukemia. It was obtained in the patients of malignant lymphoma even with poor prognostic factors. Main cause of failure was relapse shortly after transplantation and associated complications. There were 3 cases of death of acute cardiac failure related to preconditioning regimen containing high doses of cyclophosphamide and cytosine arabinoside. The studies for the proper selections of the patients for transplantation and the timing of transplantation, improvement in the methods of detection and in vitro purging of minimal residual disease cells and, the improvement in the preconditioning regimens to decrease the minimal residual disease and to decrease regimen related toxicity, are necessary for achievement of the better result of the transplantation.

[ISSN]0513-1731

[NCID]AN00243156