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Ando Toshihiko

Affiliate Master Yamaguchi University

Autologous Hematopoietic Stem Cell Transplantation in Hematological Malignancies: Results of Our Institution and Review of the Llteratures

山口医学 Volume 47 Issue 3 Page 61-69
published_at 1998-06
B030047000302.pdf
[fulltext] 5.07 MB
Title
血液悪性疾患に対する自家造血幹細胞移植 : 当科における治療成績と文献的考察
Autologous Hematopoietic Stem Cell Transplantation in Hematological Malignancies: Results of Our Institution and Review of the Llteratures
Creators Yamada Tetsuya
Creators Katsuki Kensaku
Creators Takeda Komei
Creators Kameda Naoko
Creators Ariyoshi Koichi
Creators Toyosawa Keimei
Creators Ando Toshihiko
Creators Inoue Hirofumi
Creators Nomiyama Jyun
Creators Oeda Eiichi
Source Identifiers
Creator Keywords
自家造血幹細胞移植 骨髄移植 末梢血幹細胞移植 血液悪性疾患
We performed autologous hematopoietic stem cell transplantation m the patients with hematological malignancies of 12 cases of malignant lymphoma, 3 cases of acute lymphoblastic leukemia, 2 cases acute lymphoblastic leukemia, 3 cases of multiple myeloma, I case of chronic myelogenous leukemia and I case of Ewing's sarcoma. The former 9 cases were autologous bone marrow transplantation, and recent cases were peripheral blood stem cell transplantation Long term surviving without relapse was obtained in 5 cases of malignant lymphoma and I case of acute myeloblastic leukemia. It was obtained in the patients of malignant lymphoma even with poor prognostic factors. Main cause of failure was relapse shortly after transplantation and associated complications. There were 3 cases of death of acute cardiac failure related to preconditioning regimen containing high doses of cyclophosphamide and cytosine arabinoside. The studies for the proper selections of the patients for transplantation and the timing of transplantation, improvement in the methods of detection and in vitro purging of minimal residual disease cells and, the improvement in the preconditioning regimens to decrease the minimal residual disease and to decrease regimen related toxicity, are necessary for achievement of the better result of the transplantation.
Subjects
医学 ( Other)
Languages jpn
Resource Type journal article
Publishers 山口大学医学会
Date Issued 1998-06
File Version Version of Record
Access Rights open access
Relations
[ISSN]0513-1731
[NCID]AN00243156
Schools 医学部