Severe Fever with Thrombocytopenia Syndrome Initially Diagnosed as Diffuse Large B-cell lymphoma

A 70-year-old woman presented with acute fever, impaired consciousness, leukopenia, thrombocytopenia, and right inguinal lymphadenopathy. A lymph node biopsy was diagnosed as diffuse large B-cell lymphoma (DLBCL). However, her symptoms were consistent with severe fever with thrombocytopenia syndrome (SFTS), and RT-PCR for SFTS virus (SFTSV) RNA was positive. The patient’s condition and lymphadenopathy gradually improved with supportive measures and short-term steroid treatment and no lymphadenopathy recurrence was observed. Lymph node pathological examination revealed SFTSV-infected cells, leading to the final diagnosis of necrotizing lymphadenitis associated with SFTS. Careful consideration is required to differentiate necrotizing lymphadenitis associated with SFTS from that associated with DLBCL.

Creators Ando Taishi

Creators Nakano Kohei

Creators Hayashi Shunsuke

Creators Yamashita Kohji

Creators Hatao Katsuhiro

Creators Yamashita Yoshimi

Creators Hirata Yuichiro

Creators Mine Sohtaro

Creators Katano Harutaka

Creators Suzuki Tadaki

Creators Takahashi Toru