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Sunagawa Hiroshi

Affiliate Master Yamaguchi University

Altered levels of plasma free amino acids in hyperuricemia among male smokers

The bulletin of the Yamaguchi Medical School Volume 68 Issue 1-2 Page 21-29
published_at 2021
[fulltext] 471 KB
Altered levels of plasma free amino acids in hyperuricemia among male smokers
Creators Mahbub MH
Creators Yamaguchi Natsu
Creators Hase Ryosuke
Creators Sunagawa Hiroshi
Creators Ishimaru Yasutaka
Creators Yamamoto Hiroshi
Creators Kikuchi Shinya
Creators Tanabe Tsuyoshi
Source Identifiers [PISSN] 0513-1812 [NCID] AA00594272
Creator Keywords
Amino acids plasma profile cigarette smoking Brinkman index hyperuricemia
Purpose: The purpose was to explore the existence of distinct patterns of alterations in plasma free amino acids (PFAAs) among smokers with hyperuricemia. Methods: Venous blood samples from 169 male subjects (95 smokers and 74 nonsmokers) were analyzed for the measurements of 19 PFAAs and uric acid. Mann-Whitney U-test was applied for comparison of PFAA levels between two groups. Results: Evaluations of PFAAs made separately in smokers and non-smokers show that compared to the corresponding values for the subjects without hyperuricemia, subjects with it had significantly higher levels of isoleucine, leucine, methionine, phenylalanine, tryptophan, tyrosine and valine (P<0.05 to 0.01) and significantly lower levels of glutamine, glycine and serine (P<0.05 to 0.001) in the smoker group, and a significantly higher level of phenylalanine (P<0.05) in the nonsmoker group. Conclusions: The findings suggest that hyperuricemia may have remarkable effects on the PFAA profiles in smokers, which underscores the importance of investigations into the mechanisms underlying the effects of cigarette smoking on the possible interactive relationship between the levels of plasma uric acid and PFAAs.
Languages eng
Resource Type departmental bulletin paper
Publishers Yamaguchi University School of Medicine
Date Issued 2021
File Version Version of Record
Access Rights open access
Schools 大学院医学系研究科(医学)