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Kitahara Takashi

Affiliate Master Yamaguchi University

Determination of compatibility of fosaprepitant dimeglumine and magnesium sulfate injections by high-performance liquid chromatography

The bulletin of the Yamaguchi Medical School Volume 66 Issue 3-4 Page 45-51
published_at 2019
A050066000301.pdf
[fulltext] 582 KB
Title
Determination of compatibility of fosaprepitant dimeglumine and magnesium sulfate injections by high-performance liquid chromatography
Creators Ozaki Masakazu
Creators Kouda Kyoji
Creators Furukawa Hiroyuki
Creators Kitahara Takashi
Source Identifiers
Creator Keywords
fosaprepitant dimeglumine magnesium sulfate drug compounding high-performance liquid chromatography infrared spectroscopy
Fosaprepitant dimeglumine relieves nausea and vomiting caused by highly emetogenic chemotherapy agents such as high-dose cisplatin. Magnesium has renoprotective effects against cisplatin-induced damage. Thus, both drugs are sometimes used concomitantly, but administering them together intravenously may cause occlusion of the in-line filter. We aimed to clarify the extent to which the delivery of intravenous fosaprepitant dimeglumine is reduced by magnesium sulfate. Fosaprepitant dimeglumine was combined with magnesium sulfate and then filtered. Two ratios and concentrations of magnesium sulfate were tested (1:1 and 7:3 corresponding to 1.5 mg/mL fosaprepitant dimeglumine solution to 3.85% and 0.99% magnesium sulfate solution (v/v), respectively). The concentration of fosaprepitant dimeglumine in the filtrates was measured via high-performance liquid chromatography to determine the rate of decline in fosaprepitant dimeglumine. These experiments were performed in triplicate. When the ratio of fosaprepitant dimeglumine to magnesium sulfate was 1:1, the maximum rate of decline for fosaprepitant dimeglumine was 38.67%. At a ratio of 7:3, the maximum rate of decline was 7.62%. Fosaprepitant dimeglumine likely reacted with magnesium sulfate, which might inhibit the efficacy of fosaprepitant. To prevent this, we recommend flushing the in-line filter with 50 mL of normal saline before and after the administration of fosaprepitant dimeglumine.
Languages eng
Resource Type departmental bulletin paper
Publishers Yamaguchi University School of Medicine
Date Issued 2019
File Version Version of Record
Access Rights open access
Relations
[ISSN]0513-1812
[NCID]AA00594272
Schools 大学院医学系研究科(医学) 医学部附属病院