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Hayasaki Mineo

Affiliate Master Yamaguchi University

Prophylactic activity of ivermectin against Dirofilaria immitis infection in dogs : Establishment of effective dose and administration schedule

Japanese journal of veterinary science Volume 49 Issue 3 Page 439-445
published_at 1987
2008010283.pdf
[fulltext] 563 KB
Title
Prophylactic activity of ivermectin against Dirofilaria immitis infection in dogs : Establishment of effective dose and administration schedule
Creators Ohishi Isamu
Creators Katae Hiromi
Creators Hayasaki Mineo
Creators Nakagaki Kazuhide
Creators Tada Yusuke
Creator Keywords
Dirofilaria immitis dog ivermectin larvicidal activity
To establish a recommended dose and prophylactic program of ivermectin for preventing D. immitis infection, antilarval activity of ivermectin at 3 or 6μg/kg against one day, 30 and 60 days old larvae was evaluated. The worms were recovered from all dogs given ivermectin at 3μg/kg one day after inoculation with an average infection ratio of 21.9%. One male worm was recovered from one of 6 dogs given ivermectin at 3μg/kg 30 days after inoculation with an extremely low average infection ratio of 0.1%. Out of 6 dogs given ivermectin at 3μg/kg 60 days after inoculation, 3 animals yielded worms with a low infection ratio of 4.0%. The results suggest that ivermectin at 3μg/kg demonstrates incomplete antilarval activity against D. immitis larvae of one day, 30 and 60 days old and is not suitable to monthly or bimonthly interval mdication for preventing D. immitis infection. Small numbers of the worms were recovered from 5 of 6 dogs given ivermectin at 6μg/kg one day after inoculation with an average infection ratio of 5.7%. No worms were recovered from all dogs given ivermectin at 6μg/kg 30 and 60 days after inoculation. The results show that a single oral dose of ivermectin at 6μg/kg, though the dose demonstrates incomplete antilarval activity against one day old larvae, would be a recommended dose which can completely kill the larvae which are naturally infected at any time when the dose is given once a month at one month interval during the period from one month after the first infection to one month after the last infection of D. immitis.
Languages eng
Resource Type journal article
Publishers 日本獣医学会
Date Issued 1987
File Version Version of Record
Access Rights open access
Relations
[ISSN]0021-5295
[NCID]AA10521639
[isVersionOf] [URI]http://www.jstage.jst.go.jp/browse/jvms/-char/ja
[isVersionOf] Dirofilaria immitis infection and dirofilariosis : an animal model of human filariosis [URI]http://www.lib.yamaguchi-u.ac.jp/yunoca/handle/2010010511
Schools 農学部