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Chikama Tai-ichiro

Affiliate Master Yamaguchi University

A new treatment for neurotrophic keratopathy

山口医学 Volume 49 Issue 6 Page 519-525
published_at 2000-12-30
B030049000601.pdf
[fulltext] 1.06 MB
Title
神経麻痺性角膜症に対する新しい治療法
A new treatment for neurotrophic keratopathy
Creators Chikama Tai-ichiro
Source Identifiers
Creator Keywords
神経麻痺性角膜症 創傷治癒 サブスタンスP インスリン様成長因子ー1
Homeostasis of the corneal epithelium is maintained by the actions of various biological mediators. We have shown that the neurotransmitter substance P [or the substance P-derived peptide phenylalanine-glycine-leucine-methionine amide (FGLM)] and insulin-like growth factor-1 (IGF-1) synergistically promote corneal epithelial migration in response to epithelial injury both in vitro and in vivo. The combination of substance P (or FGLM) and IGF-1 increases the expression by corneal epithelial cells of integrin α5 and β1 subunits, which together form the receptor for fibronectin and are required for the adherence of epithelial cells to the basement membrane. In clinical trials, we have also shown that the application of eye drops containing FGLM and IGF-1 is effective in the treatment of neurotrophic keratopathy, an otherwise intractable disease of the cornea. These observations suggest that neural regulation plays an important role in maintenance of corneal epithelial homeostasis.
Subjects
医学 ( Other)
Languages jpn
Resource Type journal article
Publishers 山口大学医学会
Date Issued 2000-12-30
Rights
本文データは山口大学医学会の許諾に基づきCiNiiから複製したものである()
File Version Version of Record
Access Rights open access
Relations
[ISSN]0513-1731
[NCID]AN00243156
[isVersionOf] [NAID]http://ci.nii.ac.jp/naid/110002774035/
Schools 医学部