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Yoshino Shigefumi

Affiliate Master Yamaguchi University

Effect of intrapleural and/or intraperitoneal lentinan therapy patients with malignant pleural and/or peritoneal effusion

山口医学 Volume 40 Issue 1 Page 143-152
published_at 1991-02
Title
癌性胸腹水に対するlentinan腹腔内投与療法ならびに免疫学的検討
Effect of intrapleural and/or intraperitoneal lentinan therapy patients with malignant pleural and/or peritoneal effusion
Creators Yoshino Shigefumi
Source Identifiers
Twenty lesions of sixteen patients with malignant pleural and/or peritoneal effusion were treated with the intrapleural and/or intraperitoneal lentinan therapy (4mg/week×4). And the following results were obtained. Malignant effusion disappeared in six lesions and diminiched in two. In thirteen lesions, the cytological grade decreased. Totally, sixteen lesions (80%) revealed clinical effect. Toxicity caused a high fever in only one case. Subpoplations (CD4^+, CD8^+, CD8^+CD11^+, CD8^+CD11^-) of pleural or peritoneal effusion lymphocytes and peripheral blood lymphocytes showed no change during the course of lentinan therapy. NK activites of peripheral blood mononuclear cells (PBM) after this treatment were significantly lower (P<0.05) than before treatment. However, NK and anti-Daudi activities of pleural or peritoneal effusion mononuclear cells (PEM tended to be augmented and high LAK activities of PEM were maintained by lentinan therapy. Augmentation of cytotoxicity in PEM induced by lentinan may lead to clinical effect. Patients with high NK activitied of PBM before treatment showed clinical effect. Thus, this therapy may be useful even for patients with malignant pleural or peritoneal effusion.
Subjects
医学 ( Other)
Languages jpn
Resource Type journal article
Publishers 山口大学医学会
Date Issued 1991-02
File Version Not Applicable (or Unknown)
Access Rights metadata only access
Relations
[ISSN]0513-1731
[NCID]AN00243156
Schools 医学部