膵癌切除例に対する術中門脈内,術後肝動脈内抗癌剤投与の意義 : 特に早期肝転移防止の効果

Usefulness of operative portal vein and postoperative hepatic arterial infusion chemotherapy after resection of pancreatic cancer. : with special reference for preventing liver metastasis

Creators Morita Nobuyoshi

Creators Noshima Shinji

Creators Enoki Tadahiko

Creators Takahashi Tsuyoshi

Creators Shinagawa hidenori

Creators Orita Masahiko

Creators Inokuchi Tomohiro

Creators Okamura Keiji

Creators Hayashi Daisuke

Creators Kobayashi Yuko

Creators Esato Kensuke

This study was undertaken to determine whether or not intraportal and intrahepatic arterial one-shot infusion chemotherapy can prevent hepatic metastasis after resection of pancreatic cancer. Eight patients received 20 mg of mitomycin C in the portal vein during the operation and postoperatively they received 20 mg of mitomysin C in the hepatic artery by Seldinger's method at three-month intervals(Group A). Fifteen patients received no chemotherapy before or after the operation (Group B). The histological type and size of the tumor , nodular involvement and the degree of surrounding tissue invasion did not differ significantly between the two groups. The cumulative survival rates at 1, 2 and 3 years were 100%, 60% and 20% respectively after resection in Group A. On the other hand, in Group B, the cumulative survival rates 1, 2 and 3 years after resection were 44%, 17% and 7% respectively. There was no statistically significant difference between Group A and Group B. But in Group A, no patient died from recurrence of cancer with in one year and 8 patients died of cancer recurrence in Group B. The recurrent forms of cancer in Group B were liver metastasis in 6 patients and local recurrence in 2 patients. Therefore, our method seems beneficial for preventing hepatic metastasis for patients who have received resection of pancreatic cancer.

[ISSN]0513-1731

[NCID]AN00243156