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Muto Masahiko

Affiliate Master Yamaguchi University

Genotyping of human killer cell immunoglobulin-like receptor genes in Japanese patients with psoriatic arthritis, generalized pustular psoriasis or psoriasis vulgaris

The bulletin of the Yamaguchi Medical School Volume 58 Issue 3-4 Page 37-43
published_at 2011
A050058000303.pdf
[fulltext] 549 KB
Title
Genotyping of human killer cell immunoglobulin-like receptor genes in Japanese patients with psoriatic arthritis, generalized pustular psoriasis or psoriasis vulgaris
Creators Nemoto Kei
Creators Muto Masahiko
Source Identifiers
Creator Keywords
susceptibility to psoriasis human leukocyte antigen natural killer cells killer cell immunoglobulin-like receptors
The interaction of HLA-C with killer immunoglobulin-like receptors (KIRs) on natural killer cells and some natural killer-T cells together with a strong association between HLA (human leukocyte antigen), especially HLA-Cw*06, and psoriasis indicates that this is an immune-mediated disorder. The association between KIRs and psoriatic arthritis (PA) and generalized pustular psoriasis (GPP) was investigated by typing 14 KIR genes from Japanese patients with GPP, PA or psoriasis vulgaris (PV) using PCR. Frequencies of KIR2DS1 and KIR2DL5, which was in linkage disequilibrium with KIR2DS1, were significantly increased in PV cases when compared with controls. We report an increase in KIR2DS1 and KIR2DL5 in Japanese patients with GPP and PV. The KIR haplotype (KIR2DS1+2DS2+2DS3) in PA cases occurred more frequently than in GPP and PV cases. Thus, KIR2DS1 may be a common factor in susceptibility to psoriasis, although the variation in the frequencies of HLA-C and KIRs in cases of PV, GPP, and PA indicates that other genetic factors are also involved.
Languages eng
Resource Type departmental bulletin paper
Publishers Yamaguchi University School of Medicine
Date Issued 2011
File Version Version of Record
Access Rights open access
Relations
[ISSN]0513-1812
[NCID]AA00594272
Schools 医学部附属病院 大学院医学系研究科(医学)