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Fujii Hiroyuki

Affiliate Master Yamaguchi University

Palladium-catalyzed heteroarylamination of ethyl 2-chloro-1-azaazulene-3-carboxylate and annulation of heteroarylamino-1-azaazulenes

Heterocycles Volume 79 Issue 1 Page 319-324
published_at 2009-04
2009010028.pdf
[fulltext] 67.5 KB
Title
Palladium-catalyzed heteroarylamination of ethyl 2-chloro-1-azaazulene-3-carboxylate and annulation of heteroarylamino-1-azaazulenes
Creators Koizumi Kazuya
Creators Shimabara Kunitaka
Creators Takemoto Aya
Creators Yamazaki Shinya
Creators Yamauchi Noriko
Creators Fujii Hiroyuki
Creators Kurosawa Masaki
Creators Konakahara Takeo
Creators Abe Noritaka
The palladium catalyzed heteroarylamination of ethyl 2-chloro-1-azaazulene-3-carboxylate was achieved using a catalyst based on Pd2(dba)3 / Xantphos system. Treatment of ethyl 2-(heteroarylamino)-1-aza-azulene-3-carboxylates with a PPA-POCl3 mixture gave corresponding annulation products. 2-(2-Benzothiazolylamino)-1-azaazulene (3h) showed anticancer activity against HeLa S3 cells (IC50: 6.5 μM).
Languages eng
Resource Type journal article
Publishers 日本複素環化学研究所
Date Issued 2009-04
File Version Author’s Original
Access Rights open access
Relations
[ISSN]0385-5414
[NCID]AA00663739
https://doi.org/10.3987/COM-08-S(D)6
[isVersionOf] [URI]http://www.heterocycles.jp/
Schools 大学院医学系研究科(理学) 総合科学実験センター