Fujii Hiroyuki
Affiliate Master
Yamaguchi University
Palladium-catalyzed heteroarylamination of ethyl 2-chloro-1-azaazulene-3-carboxylate and annulation of heteroarylamino-1-azaazulenes
Heterocycles Volume 79 Issue 1
Page 319-324
published_at 2009-04
Title
Palladium-catalyzed heteroarylamination of ethyl 2-chloro-1-azaazulene-3-carboxylate and annulation of heteroarylamino-1-azaazulenes
Creators
Koizumi Kazuya
Creators
Shimabara Kunitaka
Creators
Takemoto Aya
Creators
Yamazaki Shinya
Creators
Yamauchi Noriko
Creators
Kurosawa Masaki
Creators
Konakahara Takeo
The palladium catalyzed heteroarylamination of ethyl 2-chloro-1-azaazulene-3-carboxylate was achieved using a catalyst based on Pd2(dba)3 / Xantphos system. Treatment of ethyl 2-(heteroarylamino)-1-aza-azulene-3-carboxylates with a PPA-POCl3 mixture gave corresponding annulation products. 2-(2-Benzothiazolylamino)-1-azaazulene (3h) showed anticancer activity against HeLa S3 cells (IC50: 6.5 μM).
Languages
eng
Resource Type
journal article
Publishers
日本複素環化学研究所
Date Issued
2009-04
File Version
Author’s Original
Access Rights
open access
Relations
[ISSN]0385-5414
[NCID]AA00663739
[isVersionOf]
[URI]http://www.heterocycles.jp/