オーファン受容体は宝のヤマ?

Orphan G-protein coupled receptors are fruitful sources for drug discovery

Creators Mizukami Yoichi

Functional genomics can be defined as the seach for the physiological role of a gene for which its primary sequence is known. Most of the gene encoding proteins containing seven hydrophobic regions code for G protein-coupled receptors (GPCRs). GPCRs from a large and multi-gene superfamily with many important physiological functions, and have become to important targets in pharmaceutical reseach. Although many of GPCRs have been identified the natural ligands. The ligands for the other GPCRs are presently unknown. These GPCRs are called orphan receptors. Here, we examine the expression of varios orphan receptors in H9c2 cells during ischemic hypoxia and reoxygenation. Among orphan receptors examined, the level of G protein-coupled receptor 41 (GPR41) mRNA increases significantly with a peak at 2 hrs after reoxygenation, and recovers to the control level by 3 hrs after reoxygenation. …

本文データは山口大学医学会の許諾に基づきCiNiiから複製したものである()

[ISSN]0513-1731

[NCID]AN00243156

[isVersionOf] [NAID]http://ci.nii.ac.jp/naid/110002774139/