1,1,1-Trichloroethane 吸入暴露による呼吸と血液ガス分圧の変化

Effects of 1, 1, 1-Trichloroethance Inhalation on Respiration and Blood Gas Tension

Creators Kobayashi Haruo

Creators Hobara Tatsuya

Creators Kawamoto Toshihiro

Creators Higashihara Eiji

Creators Sato Toshinobu

Creators Tanaka Haruko

Creators Iwamoto Susumu

Creators Sakai Tsunemi

Changes in respiration and arterial blood gas tension following 1, 1, 1 -trichloroethane (1, 1, 1 -TCE) inhalation were investigated in anesthetized dogs. In acute in halation experiments, both increase in respiratory rate and a decrease in amplitude of respiration were observed following inhalation of higher 1, 1, 1 -TCE concentrations. The threshold concentration of 1, 1, 1 -TCE required to produce a increase in respiratory rate was approximately 0.7 to 0.9% in inspired air, and dose response relationship between the increase in respiratory rate and 1, 1, 1 -TCE concentrations which exceeded the threshold level was observed. Moreover, a trancient increase in arterial oxygen tension, a decrease in carbon dioxide tension and an increase in pH were observed following inhalation of higher 1, 1, 1 -TCE concentrations in spontaneous breathing. However, oxygen tension, carbon dioxide tension and pH remained unchanged following inhalation in artificial breathing. It is suggested that alterations of blood gas tension and pH may be based on mainly the increase in respiratory rate resulting from 1, 1, 1 -TCE inhalation in anesthetized dogs.

[ISSN]0513-1731

[NCID]AN00243156