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Hinoda Yuji

Affiliate Master Yamaguchi University

The Current Status and Issues Concerning Monoclonal Antibody Therapy

The bulletin of the Yamaguchi Medical School Volume 51 Issue 3-4 Page 41-50
published_at 2004-12
A020051000303.pdf
[fulltext] 291 KB
Title
The Current Status and Issues Concerning Monoclonal Antibody Therapy
Creators Hinoda Yuji
Source Identifiers
Creator Keywords
monoclonal antibody HER2 epidermal growth factor receptor vascular endothelial growth factor VEGF receptor human anti-mouse antibody epithelial cell adhesion molecule cytotoxic T lymphocyte-associated antigen 4 dendritic cells
Monoclomal antibodies (mAbs) against growth factor or its receptor have raised the second wave of antibody therapy for solid tumors. Transtuzumab (humanized anti-HER2mAb) is the first mAb approved for the treatment of a solid tumor, metastatic breast cancer. Large-scale phase Ⅲ clinical trials are now ongoing to further evaluate the additive effects on chemotherapy and the efficacy as a maintenance monotherapy. Overexpression of HER2 is found only a small percentage of patients with solid tumor, whereas epidermal growth factor receptor is expressed in a variety of solid tumors with high frequency. More broadly applicable for solid tumors is anti-angiogenesis therapy because it is targeting not tumor cells but tumor vasculature. Cetuximab (chimeric anti-EGFR mAb) and bevacizumab (humanized anti-VEGF mAb)have recently been shown to be clinically of remarkable effect for metastatic colorectal cancer. The points at issue are thrombotic events of bevacizumab. In contrast to the mAbs as signal inhibitors, no apparent objective responses were seen in most clinical studies of mAbs against cell surface glycoproteins or adhesion molecules. However, several groups reported the survival benefit of those mAbs, in which anti-idiotypic antibody response may play an important role. In addition, some of their anti-idiotype mAbs showed the survival benefit in patients with solid tumor. Altered self-antigens have recently been attempted to intensify active immunotherapy including dendritic cell therapy. Considering that dendritic cells efficientry cross-present tumor antigens after ingesting them as immune complex those ”modest″ mAbs may be of use for dendritic cell therapy as immune complex with altered self-antigens.
Subjects
医学 ( Other)
Languages eng
Resource Type departmental bulletin paper
Publishers Yamaguchi University Graduate School of Medicine
Date Issued 2004-12
File Version Version of Record
Access Rights open access
Relations
[ISSN]0513-1812
[NCID]AA00594272
Schools 医学部