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Ichiyama Takashi

Affiliate Master Yamaguchi University

Immunoglobulin G1 allotypes in intravenous immunoglobulin non-responders of kawasaki disease patients

The bulletin of the Yamaguchi Medical School Volume 55 Issue 3-4 Page 27-33
published_at 2008
A050055000302.pdf
[fulltext] 631 KB
Title
Immunoglobulin G1 allotypes in intravenous immunoglobulin non-responders of kawasaki disease patients
Creators Takegawa Tsuyoshi
Creators Matsubara Tomoyo
Creators Okuda Masayuki
Creators Kaneko Miho
Creators Ichiyama Takashi
Creators Furukawa Susumu
Source Identifiers
Creator Keywords
Kawasaki disease intravenous immunoglobulin G1M allotype IVIG non-responder
The standard therapy for Kawasaki disease (KD) consists of intravenous immunoglobulin (IVIG) treatment. However, at least 10% of KD patients fail to exhibit defervescence with initial IVIG therapy, and they are defined as IVIG non-responders. We investigated the prevalence of certain GM allotypes in IVIG responder and non-responder KD patients. Sera obtained from 83 KD patients and 34 controls were tested for G1M(1), G1M(2), G1M(3), and G1M(17) by using the standard agglutinationinhibition method. All the patients were treated with IVIG, and 14 patients were identified as IVIG non-responders. All samples tested were positive for the G1M(1) and G1M(17). With regard to G1M(2), 8 of 14 (57.1%) IVIG non-responders, 19 of 69 (27.5%) IVIG responders, and 7 of 34 (20.6%) controls tested were positive for this allotype. G1M(3) was detected in 9 (13%) responders, 3 (21.4%) non-responders. A significant difference in the G1M(2) distribution was noted between the non-responders and controls (p = 0.019). The G1M(2) was found to be significantly associated with the IVIG non-responders after adjustments for age, sex, and each allotype (odds ratio, 3.59
Subjects
医学 ( Other)
Languages eng
Resource Type departmental bulletin paper
Publishers Yamaguchi University School of Medicine
Date Issued 2008
File Version Version of Record
Access Rights open access
Relations
[isVersionOf] [URI]http://ds.cc.yamaguchi-u.ac.jp/~bulletin/index.html
Schools 大学院医学系研究科(医学) 大学院理工学研究科(医学)