Matsuda Masako
Affiliate Master
Yamaguchi University
Effects of left atrialadistension with exercise on α-human atrial natriuretic peptide(α-hANO) and relationship between α-hANP and exercise capacity
山口医学 Volume 40 Issue 5
Page 517-523
published_at 1991-10
Title
運動負担による心房性利尿ペプチと左心房径の変化および運動耐容能との関係について
Effects of left atrialadistension with exercise on α-human atrial natriuretic peptide(α-hANO) and relationship between α-hANP and exercise capacity
Creators
Haraguchi Masahiko
Creators
Yamagishi Takashi
Creators
Saiki Atsushi
Creators
Seto Fumio
Creators
Furutani Yuji
Creators
Ozaki Masaharu
Creators
Kusukawa Reizo
Source Identifiers
To assess the effects of left atrial distension with exercise on α-hANP and to evaluate the relationship between α-hANP and exercise tolerance, cardiopulmonary exercise testing was performed in 23 patients with prior myocardial infarction. The patients exercise on a bicycle ergometry until their exhausion. Left atrial diameter (LAD) increased significantly (P<0.01) from 31.4±6.4 to 33.3±7.8mm, and α-hANP also increased significantly (p<0.001) from 84±51 to 129±75pg/ml. Increments of LAD with exercise by LAD at rest (%Δ LAD) were positively sorrelated with changes in α-hANP (Δ α-hANP)(r=0.43, p<0.05). There was a negative correlation between peak V^^・_<O_2> and α-hANP after exercise (r=-0.45, p<0.05). Anaerbic threshold (AT) was also negatively correlated with α-hANP at rest (r=-0.52, p<0.02) and after exercise (r=-0.56, p<0.01). These indicate that exercise capacity is impaired in patients whose levels of α-hANP are elevated. Thus, left atrial distension may stimulate secreation of α-hANP. Cardiac patients with low exercise capacity have increased α-hANP before and after exercise.
Languages
jpn
Resource Type
journal article
Publishers
山口大学医学会
Date Issued
1991-10
File Version
Not Applicable (or Unknown)
Access Rights
metadata only access
Relations
[ISSN]0513-1731
[NCID]AN00243156
Schools
医学部