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Fujii Yasuhiko

Affiliate Master Yamaguchi University

Development of Alloantibodies to Non-HLA Systems in Patients on Trans fusion Therapy

The bulletin of the Yamaguchi Medical School Volume 30 Issue 1 Page 31-38
published_at 1983-12
A020030000104.pdf
[fulltext] 580 KB
Title
Development of Alloantibodies to Non-HLA Systems in Patients on Trans fusion Therapy
Creators Yasuhiko Fujii
Source Identifiers
Creator Keywords
alloantibody Non-HLA antigen HLA antigen Blood transfusion
Nineteen patients with aplastic anemia or hematological malignancies were prospectively examined with regard to the development of alloantibodies following blood transfusions. Sera obtained at regular intervals were serologically analyzed to detect the lymphocytotoxic antibodies against T cells, B cells and monocytes from a panel of unrelated subjects or their HLA-identical siblings, and the following results were obtained. Anti-HLA-A,B,C, and DR antibodies were detected in 9 out of 19 patients. Among 9 patients who received the preceding transfusions, three had the preformed antibodies. One patient who underwent the preceding pregnancies was already sensitized. Five out of the 15 nonsensitized patients developed transfusion-induced alloantibodies during the period of this study. Three out of the 19 patients demonstrated B cell specific antibodies. The development of anti-HLA-DR antibodies and B cell specific antibodies prior to the occurrence of anti-HLA-A,B and Cantibodies was observed in 3 cases. The development of monocyte specific antibodies was notobserved in this study. The development of these alloantibodies was not dependent on the total volume of blood components transfused. From these results, it is concluded that blood transfusions to the selected candidates for bone morrow transplantation should be reduced to the minimum unless indicated by urgent medical necessity.
Subjects
医学 ( Other)
Languages eng
Resource Type departmental bulletin paper
Publishers Yamaguchi University Graduate School of Medicine
Date Issued 1983-12
File Version Version of Record
Access Rights open access
Relations
[ISSN]0513-1812
[NCID]AA00594272
Schools 医学部