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Sawada Tomoo

Affiliate Master Yamaguchi University

Thymic architectures for T cell production and structural and functional recovery from their radiation injuries

The bulletin of the Yamaguchi Medical School Volume 54 Issue 1-2 Page 1-7
published_at 2007
A050054000101.pdf
[fulltext] 793 KB
Title
Thymic architectures for T cell production and structural and functional recovery from their radiation injuries
Creators Fukumoto Tetsuo
Creators Adachi Yasuhiro
Creators Tokuda Nobuko
Creators Sawada Tomoo
Creators Arudchelvan Yamini
Source Identifiers
Creator Keywords
thymus thymic epithelial cells irradiation regeneration cytokines
The thymus is an important organ for producing T cells. Thymic structures consist of thymic epithelial cells among which thymocytes proliferate and maturate. The structural and functional recovery of the rat thymus after irradiation was studied morphologically and by the message expression changes of several cytokines. In this manuscript we tried to describe further details of rat thymic epithelial cells in respect to therir electron microscopic features as well as their function to interact with thymocytes. Then the mechanisms responsible for the regeneration of the thymus after irradiation were considered. Not only the reproliferation of the thymocytes but also the regeneration of the vasculatures and thymic epithelial cells are considered important for thymus regeneration. Cytokine message changes were shown to be seriously involved for the degree of recovery of the thymus tissue after irradiation.
Subjects
医学 ( Other)
Languages eng
Resource Type departmental bulletin paper
Publishers Yamaguchi University School of Medicine
Date Issued 2007
File Version Version of Record
Access Rights open access
Relations
[isVersionOf] [URI]http://ds.cc.yamaguchi-u.ac.jp/~bulletin/index.html
Schools 医学部