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Sugino Norihiro

Affiliate Master Yamaguchi University

An invited review following the Soujinkai Award : tissue-specific expression of estrogen receptor1 is regulated by DNA methylation in a T-DMR

The bulletin of the Yamaguchi Medical School Volume 64 Issue 3-4 Page 13-19
published_at 2017
A050064000301.pdf
[fulltext] 754 KB
Title
An invited review following the Soujinkai Award : tissue-specific expression of estrogen receptor1 is regulated by DNA methylation in a T-DMR
Creators Maekawa Ryo
Creators Sugino Norihiro
Source Identifiers
Creator Keywords
estrogen receptor 1 (ESR1) tissue-specific expression DNA methylation tissue-dependent and differentially methylated region breast cancer
ESR1 expression was tissue-specific, being high in the endometrium and mammary gland and low/nil in the placenta and skin.A long-standing question was how this tissue-specific expression of ESR1 was regulated. In other genes, DNA methylation of a region called the T-DMR (tissue-dependent and differentially methylated region) has been associated with tissue-specific gene expression.We recently found that human ESR1 has a T-DMR and DNA methylation of the T-DMR, but not the promoter region, regulates its tissue-specific expression. Furthermore, we revealed that EGR1 is a possible transcription factor to bind the T-DMR and upregulate ESR1 expression under DNA hypomethylation of the T-DMR.
Languages eng
Resource Type departmental bulletin paper
Publishers Yamaguchi University School of Medicine
Date Issued 2017
File Version Version of Record
Access Rights open access
Relations
[ISSN]0513-1812
[NCID]AA00594272
Schools 医学部附属病院 大学院医学系研究科(医学)