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Hattori Yukio

Affiliate Master Yamaguchi University

Futher Examples of Hemoglobin Hirose : Study of Molecular Stability

The bulletin of the Yamaguchi Medical School Volume 30 Issue 1 Page 21-30
published_at 1983-12
A020030000103.pdf
[fulltext] 1.49 MB
Title
Futher Examples of Hemoglobin Hirose : Study of Molecular Stability
Creators Ohba Yuzo
Creators Hattori Yukio
Creators Takeda Isamu
Creators Fuyuno Kikuo
Creators Matsuoka Miyoko
Creators Yoshinaka Hiroshi
Creators Satoh Tomoki
Creators Miyaji Takaoki
Source Identifiers
Creator Keywords
Abnormal hemoglobin
Two new cases of Hb Hirose,β37 (CⅢ) Trp→Ser, are reported. Hemoglobin Hirose exhibits propreties, a high oxygen affinity and slightly increased rates of autooxidation, heat denaturation and precipitation on mechanical shaking. These unique properties of Hb Hirose seem to depend on the abnormal manner of association of the aberrant β subunit with the α submit and on the enhanced tendency to dissociate intosubunits. In spite of the abnormal functional properties and the molecular instability of the hemoglobin, none of the carries of Hb Hirose reported so far (only four unrelated Japanese in the world) manifested erythrocytosis or a hemolytic disorder, presumably because the dissociation into subnit is prevent in vivo by the very high hemogrobin concentration in the red blood cell.
Subjects
医学 ( Other)
Languages eng
Resource Type departmental bulletin paper
Publishers Yamaguchi University Graduate School of Medicine
Date Issued 1983-12
File Version Version of Record
Access Rights open access
Relations
[ISSN]0513-1812
[NCID]AA00594272
Schools 医学部