Sasaki Kohsuke
Affiliate Master
Yamaguchi University
Identification of the copy number aberrations for determining the disease stage of colorectal cancers : the application of a multifactor dimensionality reduction (MDR) method to an array-based CGH
The bulletin of the Yamaguchi Medical School Volume 56 Issue 3-4
Page 49-55
published_at 2009
Title
Identification of the copy number aberrations for determining the disease stage of colorectal cancers : the application of a multifactor dimensionality reduction (MDR) method to an array-based CGH
Source Identifiers
Creator Keywords
array based CGH
multifactor dimensionality reduction (MDR) method
cross validation test
The clinical application of array CGH technology is eagerly awaited. It is necessary to clarify the genome markers closely associated with the clinical condition. The multifactor dimensionality reduction method (henceforth, MDR) analysis was applied to the array CGH data of 74 cases colorectal cancer in order to identify two or more spot clones, i.e., a clone marker, with the maximum separation ability between low stage and a high stage lesions. The optimal marker in one clone was 8q24.3 (Accuracy 0.7027, Sensitivity 0.9688, Specificity 0.5000), the optimal markers in two clones were 7q36.3 and 22q11.1 (Acc. 0.8108, Sen. 0.8438, Spe. 0.7857)…
Languages
eng
Resource Type
departmental bulletin paper
Publishers
Yamaguchi University School of Medicine
Date Issued
2009
File Version
Version of Record
Access Rights
open access
Relations
[isVersionOf]
[URI]http://ds.cc.yamaguchi-u.ac.jp/~bulletin/index.html
Schools
大学院医学系研究科（医学）