運動負担による心房性利尿ペプチと左心房径の変化および運動耐容能との関係について

Effects of left atrialadistension with exercise on α-human atrial natriuretic peptide(α-hANO) and relationship between α-hANP and exercise capacity

Creators Haraguchi Masahiko

Creators Yamagishi Takashi

Creators Saiki Atsushi

Creators Seto Fumio

Creators Furutani Yuji

Creators Matsuda Masako

Creators Ozaki Masaharu

Creators Matsuzaki Masunori

Creators Kusukawa Reizo

To assess the effects of left atrial distension with exercise on α-hANP and to evaluate the relationship between α-hANP and exercise tolerance, cardiopulmonary exercise testing was performed in 23 patients with prior myocardial infarction. The patients exercise on a bicycle ergometry until their exhausion. Left atrial diameter (LAD) increased significantly (P＜0.01) from 31.4±6.4 to 33.3±7.8mm, and α-hANP also increased significantly (p＜0.001) from 84±51 to 129±75pg/ml. Increments of LAD with exercise by LAD at rest (%Δ LAD) were positively sorrelated with changes in α-hANP (Δ α-hANP)(r＝0.43, p＜0.05). There was a negative correlation between peak V^^・_<O_2> and α-hANP after exercise (r＝-0.45, p＜0.05). Anaerbic threshold (AT) was also negatively correlated with α-hANP at rest (r＝-0.52, p＜0.02) and after exercise (r＝-0.56, p＜0.01). These indicate that exercise capacity is impaired in patients whose levels of α-hANP are elevated. Thus, left atrial distension may stimulate secreation of α-hANP. Cardiac patients with low exercise capacity have increased α-hANP before and after exercise.

[ISSN]0513-1731

[NCID]AN00243156