Survival of mouse ovarian tissue transplanted into the uterine horn of post-partum rats nursing pups of various numbers and sizes

Creators Kagabu Satosi

Creators Umezu Motoaki

Aim and background: To investigate the effect of the number of pups being nursed on the survival of mouse ovarian tissue transplanted into the post-partum rat uterus. Methods: Mouse ovarian tissue was transplanted into the uterine horn of post-partum rats. The number of pups nursed by each recipient rat was adjusted in a manner predetermined. Examinations were undertaken at 1-11 weeks after transplantation. Ovarian tissue containing healthy follicles was considered to have taken successfully. Results: In rats with 12 pups, ovarian tissue remained viable at 11 weeks post-transplantation. No viable ovarian tissue remained when there were one or two pups. Viability improved as the number of pups increased. Conclusion: When mouse ovarian tissue is transplanted into post-partum lactating rats, viability improves as the number of pups increases. We concluded that these findings may be explained in terms of progesterone levels in the recipient rats.

[ISSN]1445-5781

[NCID]AA11706516

info:doi/10.1111/j.1447-0578.2005.00095.x

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