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Abe Noritaka

Affiliate Master Yamaguchi University

Syntheses and some reactions of 4H-cyclohepta[4,5]-pyrrolo[1,2-a]pyrimidin-4-ones

Bulletin of the Chemical Society of Japan Volume 60 Issue 3 Page 1053-1056
published_at 1987
Title
Syntheses and some reactions of 4H-cyclohepta[4,5]-pyrrolo[1,2-a]pyrimidin-4-ones
Creators Abe Noritaka
The reaction of 2-aminocyclohepta[b]pyrroles with ethyl acetoacetate in phoshoryl chloride-polyphosphoric acid gives 2-methyl-4H-cyclohepta[4,5]pyrrolo[1,2-a]pyrimidin-4-ones. A ring closure of diethyl N-(cyclohepta[b]pyrrol-2-yl)aminomethylenemalonates gives 4-oxo-4H-cyclohepta[4,5]pyrrolo[1,2-a]pyrimidine-3-carboxylates (2) in phosphoryl chloride-polyphosphoric acid or in hot t-butylbenzene, which are deesterified by the treatment with hot hydrobromic acid. Compounds 2 undergo replacement reactions towards some electrophiles at positions C-3, C-11, and C-7 (in that order).
Languages eng
Resource Type journal article
Publishers 日本化学会
Date Issued 1987
File Version Not Applicable (or Unknown)
Access Rights metadata only access
Relations
[ISSN]0009-2673
[NCID]AA00580132
info:doi/10.1246/bcsj.60.1053
[isVersionOf] [URI]http://www.jstage.jst.go.jp/browse/bcsj/-char/en
Schools 大学院医学系研究科(理学)