Syntheses and some reactions of 4H-cyclohepta[4,5]-pyrrolo[1,2-a]pyrimidin-4-ones
Bulletin of the Chemical Society of Japan Volume 60 Issue 3
Page 1053-1056
published_at 1987
Title
Syntheses and some reactions of 4H-cyclohepta[4,5]-pyrrolo[1,2-a]pyrimidin-4-ones
The reaction of 2-aminocyclohepta[b]pyrroles with ethyl acetoacetate in phoshoryl chloride-polyphosphoric acid gives 2-methyl-4H-cyclohepta[4,5]pyrrolo[1,2-a]pyrimidin-4-ones. A ring closure of diethyl N-(cyclohepta[b]pyrrol-2-yl)aminomethylenemalonates gives 4-oxo-4H-cyclohepta[4,5]pyrrolo[1,2-a]pyrimidine-3-carboxylates (2) in phosphoryl chloride-polyphosphoric acid or in hot t-butylbenzene, which are deesterified by the treatment with hot hydrobromic acid. Compounds 2 undergo replacement reactions towards some electrophiles at positions C-3, C-11, and C-7 (in that order).
Languages
eng
Resource Type
journal article
Publishers
日本化学会
Date Issued
1987
File Version
Not Applicable (or Unknown)
Access Rights
metadata only access
Relations
[ISSN]0009-2673
[NCID]AA00580132
[isVersionOf]
[URI]http://www.jstage.jst.go.jp/browse/bcsj/-char/en
Schools
大学院医学系研究科（理学）