Effects of Intraventricular Osmotis Pressure on the Formation Rate of Cerebraspinal Fluid and Subsequent Distribution of Electrolytes Between the Fluid and Serum in Rabbits.
The bulletin of the Yamaguchi Medical School Volume 19 Issue 3-4
Page 133-148
published_at 1972-12
Title
Effects of Intraventricular Osmotis Pressure on the Formation Rate of Cerebraspinal Fluid and Subsequent Distribution of Electrolytes Between the Fluid and Serum in Rabbits.
Creators
Maza Takuma
Source Identifiers
Ventriculocicternal perfusions with artificial CSF were carried out in rabbits. The rate of formation of CSF in the contral animals was found to be 10.9±0.5μl/min. Hypertonic perfusion was performed by adding NaCl or monosaccharides into the perfusion fluid and the osmotic influence these had upon CSF formation was investigated. A remarkable incease in the rate of formation of CSF was observed in the NaCl group, after a steady atate was achieved in the perfusion system, while in the xylose-glucose group, the increase in the rate of formation of CSF was not only less marked but also of shorter duration, despite increased osmolality of the porfusate. In the xylose-glucose group, when the osmotic gradient between porfusate and serum was produced by the addition of sugars to the porfusate, we found that there probably existed a critical ,agnitude of osmotic gradient required in order to initiate osmotic flow through the ependymal linings and/or choroidal epithelium. We estimated this cirtical value to be approximately 30 mOsm/L. Analysis of electrolytes in the effluent revealed no remarkable alteration during perfusion with hyperosmotic slutions when compared with those of the contrals, expect for concentrations of Na+ and Cl- in the NaCl group. The active transport of electrolytes followed by diffusion of water, saturation of a sugar-transport mechanism, and regulation of electrolyte concentration in the ventricular system are all thought to be factors contributing to the homeostatic mechanism which regu
Languages
eng
Resource Type
departmental bulletin paper
Publishers
Yamaguchi University Graduate School of Medicine
Date Issued
1972-12
File Version
Version of Record
Access Rights
open access
Relations
[ISSN]0513-1812
[NCID]AA00594272
Schools
医学部