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Early Phase II Study of Hypoxic Cell Radiosensitizer RK28 in Yamaguchi University School of Medicine and Shimonoseki General Municipal Hospital

山口医学 Volume 41 Issue 1 Page 29-36
published_at 1992-02
Title
放射線増感剤RK28前期第II相試験結果 : 山口大学医学部付属病院および下関市立中央病院における集計
Early Phase II Study of Hypoxic Cell Radiosensitizer RK28 in Yamaguchi University School of Medicine and Shimonoseki General Municipal Hospital
Creators Ebe kazuyu
Creators Nagaoka Sakae
Creators Arita takeshi
Creators Suda hiroki
Creators Honma Yutaka
Creators Chozi Takashi
Creators Soezima Kyoko
Creators Kawamura Mitsutoshi
Creators Okada Morihisa
Creators Karino Yuichi
Creators Nakada Taishi
Creators Nakanishi Takashi
Source Identifiers
Creator Keywords
放射線増感剤 RK28 前期第II相試験 静注 動注 局注
Fifteen patients with malignant tumors were entered into an early phase II study of hypoxic cell radiosensitive RK28 during Nov. 1989 to Mar. 1991. The treatment regimen consisted of a 0.4g/m^2 IV, I A infusion twice a week or LI(local injection). Fourteen patients were evaluable for response. Six partial responses were observed. The main adverse effect was nausea/vomiting (53%). The results of animal experiments in RK28 I A infusion on rabbit VX2 tumor system were also demonstrated.
Subjects
医学 ( Other)
Languages jpn
Resource Type journal article
Publishers 山口大学医学会
Date Issued 1992-02
File Version Not Applicable (or Unknown)
Access Rights metadata only access
Relations
[ISSN]0513-1731
[NCID]AN00243156
Schools 医学部