Early Phase II Study of Hypoxic Cell Radiosensitizer RK28 in Yamaguchi University School of Medicine and Shimonoseki General Municipal Hospital
山口医学 Volume 41 Issue 1
Page 29-36
published_at 1992-02
Title
放射線増感剤RK28前期第II相試験結果 : 山口大学医学部付属病院および下関市立中央病院における集計
Early Phase II Study of Hypoxic Cell Radiosensitizer RK28 in Yamaguchi University School of Medicine and Shimonoseki General Municipal Hospital
Creators
Ebe kazuyu
Creators
Nagaoka Sakae
Creators
Arita takeshi
Creators
Suda hiroki
Creators
Honma Yutaka
Creators
Chozi Takashi
Creators
Soezima Kyoko
Creators
Kawamura Mitsutoshi
Creators
Okada Morihisa
Creators
Karino Yuichi
Creators
Nakada Taishi
Creators
Nakanishi Takashi
Source Identifiers
Creator Keywords
放射線増感剤
RK28
前期第II相試験
静注
動注
局注
Fifteen patients with malignant tumors were entered into an early phase II study of hypoxic cell radiosensitive RK28 during Nov. 1989 to Mar. 1991. The treatment regimen consisted of a 0.4g/m^2 IV, I A infusion twice a week or LI(local injection). Fourteen patients were evaluable for response. Six partial responses were observed. The main adverse effect was nausea/vomiting (53%). The results of animal experiments in RK28 I A infusion on rabbit VX2 tumor system were also demonstrated.
Languages
jpn
Resource Type
journal article
Publishers
山口大学医学会
Date Issued
1992-02
File Version
Not Applicable (or Unknown)
Access Rights
metadata only access
Relations
[ISSN]0513-1731
[NCID]AN00243156
Schools
医学部