Behavioral change and memory impairment following transient forebrain ischemia in rats with sercvere famage in CA1 sector of hippocampus
山口医学 Volume 39 Issue 1
Page 111-120
published_at 1990-02
Title
一過性脳虚血後の行動・記憶の異常と神経細胞障害に関する研究
Behavioral change and memory impairment following transient forebrain ischemia in rats with sercvere famage in CA1 sector of hippocampus
Creators
Nakayama Hideto
Source Identifiers
Behavioral change and memory impairment following transient forebrain ischemia were studied in rats. Ischemia was indeced by a combination of bilateral common carotid artery occlusion and induced hypotension. During the recovery period, behavioral change was evaluated by openfield method. Active avoidance response was used for quantitive analysis of memory desturbance. Histopathological examination was performed 7 days after ischmic insult. Ischemia caused marked elevation in locomoter activity and suppressed preening and grooming. Conditioned avoidance respone was significantly disturbed after ischemic insult. Forebrain ischemia produced severe neuronal necrosis in CA1 sector of hippocampus, while lesser damage in caudate putamen and neocortex. These results suggest that severe neuronal damage in CA1 sector produces behavioral change and memory impairment after forebrain ischemia in rats.
Languages
jpn
Resource Type
journal article
Publishers
山口大学医学会
Date Issued
1990-02
File Version
Not Applicable (or Unknown)
Access Rights
metadata only access
Relations
[ISSN]0513-1731
[NCID]AN00243156
Schools
医学部