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Changes of gastric mucosal cell kinetics in experimental rat stress ulcer : application of flow cytometry

山口医学 Volume 37 Issue 6 Page 451-457
published_at 1988-12
Title
ラット水侵拘束ストレス潰瘍における胃粘膜細胞動態の変化 : flow cytometry 応用の試み
Changes of gastric mucosal cell kinetics in experimental rat stress ulcer : application of flow cytometry
Creators Yanai Hideo
Creators Tada Masahiro
Creators Karita Mikio
Creators Oka Shinji
Creators Matsuda Kazuya
Creators Okazaki Yukinori
Creators Takemoto Tadayoshi
Source Identifiers
The Gastric mucosal cell cycle is one of the important gastric mucosal defensive factors. We studied the changes of gastric mucosal cell kinetrics in experimental stress ulcer not only by the usual bromodeoxyuridine (BrdUrd) labelling method to detect the generative cells but by flow cytometry to calculate the S phase cell ratio. S phase cell ratio decreased just after stress load no BrdUrd labelled cell was detected in ulcerative lesions. It is suspected that, the decreased cell cycle speed may be responsible for the pathogenesis of stress ulcer. At 48 hours after the stress load was completed, that S phase ratio increased more than control. It was considered to be regenerative change.
Subjects
医学 ( Other)
Languages jpn
Resource Type journal article
Publishers 山口大学医学会
Date Issued 1988-12
File Version Not Applicable (or Unknown)
Access Rights metadata only access
Relations
[ISSN]0513-1731
[NCID]AN00243156
Schools 医学部