Effect of Gyrase Inhibitors on the Activity of φBA 1
山口医学 Volume 34 Issue 6
Page 507-512
published_at 1985-12
Title
φBA 1活性に対するDNA gyrase阻害剤の影響
Effect of Gyrase Inhibitors on the Activity of φBA 1
Source Identifiers
The effect of DNA gyrase inhibitors, which contained a new quinolone compound enoxacin, nalidixic acid, and, on the two activities (plaque-forming and killing) of a phage (φBA1) of Bacillus aneurinolyticus was studied. The results obtained are as follows : 1) Minimum inhibitory concentration (MIC) of enoxacin against B. aneurinolyticus KA10 and KA23 were 6.25μg/ml and 3.13μg/ml, respectively: MICs of nalidixic acid against both strains were approx. 100μg/ml. MICs of novobiocin against the strains were 12.5μg/ml and 1.56μg/ml, respectively. 2) In the case of enoxacin and nalidixic acid, plaque-forming activity of oBA1 at the one-half concentration of MIC was reduced to about 40% compared with that of no-drug control. 3) Killing activity of φBA1 was not effected by the drugs as long as the host cell could grow.
Languages
jpn
Resource Type
journal article
Publishers
山口大学医学会
Date Issued
1985-12
File Version
Not Applicable (or Unknown)
Access Rights
metadata only access
Relations
[ISSN]0513-1731
[NCID]AN00243156
Schools
医学部