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Association with Serum Collagen Remodeling Factors and Progression of Liver Disease

山口医学 Volume 32 Issue 5 Page 507-516
published_at 1983-10
Title
肝線維化に伴う血中線維化関連因子の動態
Association with Serum Collagen Remodeling Factors and Progression of Liver Disease
Creators Fukumoto Yohei
Creators Okita Kiwamu
Creators Kado Yuji
Creators Nawata Hiroshi
Creators Ogino Masaaki
Creators Shingai Yasuji
Creators Oda Masataka
Creators Esaki Takaro
Creators Konishi Tomomi
Creators Ando Keijiro
Creators Matsuda Shoshi
Creators Noda Kenichi
Creators Kodama Takahiro
Creators Takemoto Tadayoshi
Source Identifiers
It is difficult to assume the grade of liver fibrosis from liver function test in the patients with chronic liver diseases, if histological aproach is not performed. Therefore, in order to clarify an association of serum collagen remodeling factors with liver fibrosis, serum levels of α_2-macroglobuline (α_2M), α_1-antitrypsin (α_1AT) and inter-α-trypsine inhibitor (IαTI), and histological changes of fibrosis were studied comparatively among the cases with chronic liver diseases. More over, the relationship between serum levels of α_2M or α_1AT, and serum prolyl hydroxylase activity was studied. Serum levels of α_2M and α_1AT were elevated mostly in the patients with chronic active hepatitis accompanied with lobular disorganization and active stage cirrhosis. On the other hand, these proteins having antiproteinase activity decreased among the cases carrying decompensated liver cirrhosis. Serum level of IαTI was not changed in the patients with chronic liver diseases. In conclusion, our results pointed out the usefulness to determine serum proteins concerned with proteinase inhibitors, in order to suggest the fibrosis which happened in chronic liver diseases.
Subjects
医学 ( Other)
Languages jpn
Resource Type journal article
Publishers 山口大学医学会
Date Issued 1983-10
File Version Not Applicable (or Unknown)
Access Rights metadata only access
Relations
[ISSN]0513-1731
[NCID]AN00243156
Schools 医学部