Association with Serum Collagen Remodeling Factors and Progression of Liver Disease
山口医学 Volume 32 Issue 5
Page 507-516
published_at 1983-10
Title
肝線維化に伴う血中線維化関連因子の動態
Association with Serum Collagen Remodeling Factors and Progression of Liver Disease
Creators
Fukumoto Yohei
Creators
Okita Kiwamu
Creators
Kado Yuji
Creators
Nawata Hiroshi
Creators
Ogino Masaaki
Creators
Shingai Yasuji
Creators
Oda Masataka
Creators
Esaki Takaro
Creators
Konishi Tomomi
Creators
Ando Keijiro
Creators
Matsuda Shoshi
Creators
Noda Kenichi
Creators
Kodama Takahiro
Creators
Takemoto Tadayoshi
Source Identifiers
It is difficult to assume the grade of liver fibrosis from liver function test in the patients with chronic liver diseases, if histological aproach is not performed. Therefore, in order to clarify an association of serum collagen remodeling factors with liver fibrosis, serum levels of α_2-macroglobuline (α_2M), α_1-antitrypsin (α_1AT) and inter-α-trypsine inhibitor (IαTI), and histological changes of fibrosis were studied comparatively among the cases with chronic liver diseases. More over, the relationship between serum levels of α_2M or α_1AT, and serum prolyl hydroxylase activity was studied. Serum levels of α_2M and α_1AT were elevated mostly in the patients with chronic active hepatitis accompanied with lobular disorganization and active stage cirrhosis. On the other hand, these proteins having antiproteinase activity decreased among the cases carrying decompensated liver cirrhosis. Serum level of IαTI was not changed in the patients with chronic liver diseases. In conclusion, our results pointed out the usefulness to determine serum proteins concerned with proteinase inhibitors, in order to suggest the fibrosis which happened in chronic liver diseases.
Languages
jpn
Resource Type
journal article
Publishers
山口大学医学会
Date Issued
1983-10
File Version
Not Applicable (or Unknown)
Access Rights
metadata only access
Relations
[ISSN]0513-1731
[NCID]AN00243156
Schools
医学部