Effects of Enhanced Intrinsic Adenosine by Sympathetic Stimulation on Myoeardial Blood Flow Distribution and Regional Myocardial Function in Flow Limited Canine Model

交感神経刺激による内因性アデノシン産生亢進が心筋内血流分布,局所心筋収縮性に及ぼす影響

Effects of Enhanced Intrinsic Adenosine by Sympathetic Stimulation on Myoeardial Blood Flow Distribution and Regional Myocardial Function in Flow Limited Canine Model

Creators Mikami Shunsuke

In patients with critical coronary stenosis, it has been documented that myocardial ischemia continues even after cessation of exercise. To clarify this mechanism, we studied the changes in transmural blood flow distribution and regional myoeardial function in flow limited canine model. In 29 anesthetized dogs, circumflex coronary artery was cannulated and per fused with arterial blood at constant flow rate using a roller pump. Regional wall thiekening (%WT: sonomicrometry) and calculated coronary vascular resistance (CVR) were obtained at control (c), during norepinephrine infusion (NE: 0.3/μg/kg/min, I. C,) and 2 minutes after cessation of NE infusion (R). Regional myocardial blood flow was measured by eolored microspheres at C and R. This protocol was performed with (N=7) and without (n=16) adenosine receptor blockade, 8-sulfophenyl theophylline (8-SPT

[ISSN]0513-1731

[NCID]AN00243156