Toxicological studies on combined preparation of Chloramphenicol and Acetylspiramycin named 661-CA
山口医学 Volume 18 Issue 2
Page 127-138
published_at 1969-06
Title
Chloramphenicol, Acetylspiramycin 配合剤 (661-CA) の毒性実験
Toxicological studies on combined preparation of Chloramphenicol and Acetylspiramycin named 661-CA
Creators
Koyama Kaoru
Creators
Hatano Munetoshi
Creators
Hara Takuji
Creators
Miyakawa Akira
Creators
Ohguro Yuji
Creators
Kanda Kiyoo
Source Identifiers
Combined preparation of chloramphenicol (CP) and acetylspiramycin (ASPM), named 661-CA, was compared with each of the two agents in the toxicological studies. The observations are summarized as follows. 1. Acute toxicity LD_50 of CP, ASPM and 661-CA given by parenteral and oral routes to mice, rats and rabbits are shown in Table-1. 661-CA was intermediate in toxicity between CP and ASPM. 2. Subacute and chronic toxicity These three agents were administered orally to Donryu strain rats for six months. Death appeared within 27-48days in 2g/kg dose groups and the mortality is 60% in ASPM, 20% in CP and 661-CA, respectively. The cause of death may correspond with action of CP
Languages
jpn
Resource Type
journal article
Publishers
山口大学医学会
Date Issued
1969-06
File Version
Not Applicable (or Unknown)
Access Rights
metadata only access
Relations
[ISSN]0513-1731
[NCID]AN00243156
Schools
医学部