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Fever in rabbits induced by intravenous or intracerebroventricular injection of human recombinant interferon-β and -γ

山口医学 Volume 36 Issue 6 Page 347-352
published_at 1987-12
Title
インターフェロンβとインターフェロンγの家兎静脈内ならびに脳室内投与によって誘発される発熱
Fever in rabbits induced by intravenous or intracerebroventricular injection of human recombinant interferon-β and -γ
Creators Morimoto Akio
Creators Murakami Naotoshi
Source Identifiers
Interavenous (I.V.) and intracerebroventricular (I.C.V.) injection of human recombinant interferon-β and interferon-γ produced dose-dependent vers in rabbits. The fever induced by I.V. injection was monophasic and the maximum elevation occurred 90-120 min after injection. The fever induced by I.C.V. injection was observed from about 20 min after injection and was remarkably prolonged over 4 hours. The pyrogenicity of interferon-γ was greater than that of interferon-β. The development of pyrogenic tolerance to interferon-β and -γ was observed when rabbits were given. I.V. injections on 3 successive days. The present results suggest that interferon is one of endogenous mediator proteins responsible for produsing fever.
Subjects
医学 ( Other)
Languages jpn
Resource Type journal article
Publishers 山口大学医学会
Date Issued 1987-12
File Version Not Applicable (or Unknown)
Access Rights metadata only access
Relations
[ISSN]0513-1731
[NCID]AN00243156
Schools 医学部