Effects of Urokinase on pre and post-operative coagulating and fibrinolytic activity in vascular surgery
山口医学 Volume 37 Issue 1
Page 95-99
published_at 1988-02
Title
血行再建術前後の凝固線溶系に対するUrokinaseの効果
Effects of Urokinase on pre and post-operative coagulating and fibrinolytic activity in vascular surgery
Creators
Nishiyama Toshihiro
Creators
Esato Kensuke
Creators
Takenaka Hiroaki
Creators
Misumi Kohzo
Creators
Akimoto Fumikazu
Creators
Kohchi Yasuhiro
Creators
Nakamura Takashi
Source Identifiers
Urokinase (Uk) was injected postoperatively at several different doses (mean doses 22×10^4 IU/day) into 9 patients with arterial reconstruction in order to evaluate the pre and post-operative coagulating and fibrinolytic activity. The following parameters in blood coagulating and fibrinolytic activity were measured : α_2-plasmin inhibitor (α_2-PI), fibrinogen (Fbg), fibrinogen degenerative producrs (FDP), plasminogen (PLG) and antithrobin III. Levels in patients with Urokinase administrarion were compared to those in patients without Urokinase administration, who underwent general surgery. The levels of α_2-plasmin inhibitor in patients with Urokinase were statistically significantly lower at the 3rd and 7th postoperative day than those in patients without Urokinase. However, in the leels of Fbg and urine and blood FDP, there were no statistical differences between groups with Urokinase and without Urokinase, though Fbg and urine FDP levels were highest at the 1st and 3rd postoperative days. Urokinase administration was useful in preventing the early occlusion of the arterial reconstructive tract postoperatively.
Languages
jpn
Resource Type
journal article
Publishers
山口大学医学会
Date Issued
1988-02
File Version
Not Applicable (or Unknown)
Access Rights
metadata only access
Relations
[ISSN]0513-1731
[NCID]AN00243156
Schools
医学部