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Effects of Urokinase on pre and post-operative coagulating and fibrinolytic activity in vascular surgery

山口医学 Volume 37 Issue 1 Page 95-99
published_at 1988-02
Title
血行再建術前後の凝固線溶系に対するUrokinaseの効果
Effects of Urokinase on pre and post-operative coagulating and fibrinolytic activity in vascular surgery
Creators Nishiyama Toshihiro
Creators Esato Kensuke
Creators Takenaka Hiroaki
Creators Misumi Kohzo
Creators Akimoto Fumikazu
Creators Kohchi Yasuhiro
Creators Nakamura Takashi
Source Identifiers
Urokinase (Uk) was injected postoperatively at several different doses (mean doses 22×10^4 IU/day) into 9 patients with arterial reconstruction in order to evaluate the pre and post-operative coagulating and fibrinolytic activity. The following parameters in blood coagulating and fibrinolytic activity were measured : α_2-plasmin inhibitor (α_2-PI), fibrinogen (Fbg), fibrinogen degenerative producrs (FDP), plasminogen (PLG) and antithrobin III. Levels in patients with Urokinase administrarion were compared to those in patients without Urokinase administration, who underwent general surgery. The levels of α_2-plasmin inhibitor in patients with Urokinase were statistically significantly lower at the 3rd and 7th postoperative day than those in patients without Urokinase. However, in the leels of Fbg and urine and blood FDP, there were no statistical differences between groups with Urokinase and without Urokinase, though Fbg and urine FDP levels were highest at the 1st and 3rd postoperative days. Urokinase administration was useful in preventing the early occlusion of the arterial reconstructive tract postoperatively.
Subjects
医学 ( Other)
Languages jpn
Resource Type journal article
Publishers 山口大学医学会
Date Issued 1988-02
File Version Not Applicable (or Unknown)
Access Rights metadata only access
Relations
[ISSN]0513-1731
[NCID]AN00243156
Schools 医学部