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State-dependent effect of carbamazepine on analgesia in stressed and nonstressed rats

山口医学 Volume 39 Issue 3 Page 373-383
published_at 1990-06
Title
鎮痛に対するcarbomazepineの状況依存性効果について
State-dependent effect of carbamazepine on analgesia in stressed and nonstressed rats
Creators Mashimoto Shigeki
Source Identifiers
The effects of carbamazepine for analgesia (in tail flick method) and core temperature were studied in two dittetent states, i.e., stressed and nonstressed states in rats. Carbamazepine (10-50mg/kg i.p.) or immobilization stress alone did not induce significant analgesia for rats, but when carbamazepine was given in a combination with stress, it could produce a long-lasting analgesia which ecerted dual peal somponents (after 30 minutes and after 4 hours of prescripition). Carbamazepine produced initialy slight hypothrmia which was potentiated by immobilization stress. The effects of carbamazepine on analgesia induced by N^6-cyclohecyl adenosine (CHA : 0.2mg/kg i.p.), an adenosine A_1-receptor afonist, were an inhibition in nonstressed rats and stimulation in stressed rats. Initial cabazepine (25mg/kg i.p.)-induced analgesia in stressed rats was antagonized bu caffeine (5mg/kg i.p.), an adenosine antafonisr, and subsequent continuous analgesia was anatagonized by carbamazepine and morphine. These results suggest that the effect of carbamazepine on analgesia and core temperature are alterd depending upon the state of animals. Carbamazepine-induced hyperanalgesia in stressed rats is characterized in dual compoents. The initial hyperanalgesia may be due to an activation of adenosine receptors, whereas the subsequent long-lasting analgetic and antiulcerative action may be mediated by central opioid system.
Subjects
医学 ( Other)
Languages jpn
Resource Type journal article
Publishers 山口大学医学会
Date Issued 1990-06
File Version Not Applicable (or Unknown)
Access Rights metadata only access
Relations
[ISSN]0513-1731
[NCID]AN00243156
Schools 医学部