Pharmacological and Toxicological Studies on Beclometasone dipropionate
山口医学 Volume 19 Issue 1
Page 65-86
published_at 1970-03
Title
Beclometasone dipropionateの一般薬理作用と毒性
Pharmacological and Toxicological Studies on Beclometasone dipropionate
Creators
Ohguro Yuji
Creators
Kiyohara Akira
Creators
Miyagawa Akira
Creators
Imamura Satoshi
Creators
Koyama Kaoru
Creators
Hara Takuji
Source Identifiers
Pharmacological, toxicological and teratological studies on a new topical corticosteroid, beclometasone dipropionate (KW-053), were experimentally conducted. The results obtained are summarized as follows : 1. Acute toxicity : KW-053, given by various routes, was remarkably recognized low toxicity. 2. Pharmacological studies : No pharmacodynamic effects of KW-053 were demonstrated. 3. Subacute and chronic toxicity : In the rat administered KW-053 subcutaneously, there were observed the characteristic changes of treatment with an anti-inflammatory steroid, but the changes produced by KW-053 300mg/kg/day corresponded with those by dexamethasone 1mg/kg/day. In the rabbit applied steroid-ointment or -cream to the skin, there were observed the changes, too, and the changes produced by KW-053 were slighter than those by dexamethasone.
Languages
jpn
Resource Type
journal article
Publishers
山口大学医学会
Date Issued
1970-03
File Version
Not Applicable (or Unknown)
Access Rights
metadata only access
Relations
[ISSN]0513-1731
[NCID]AN00243156
Schools
医学部