Effect of Local Hyperthermia Induced by 2450 MHz Microwave on EATC Tumor in ICR Mice
山口医学 Volume 35 Issue 4
Page 215-223
published_at 1986-08
Title
ICRマウスEATC固型腫瘍に対する2450MHzマイクロ波による加温効果
Effect of Local Hyperthermia Induced by 2450 MHz Microwave on EATC Tumor in ICR Mice
Creators
Suga Kazuyoshi
Creators
Yokoyama Takashi
Creators
Sawamura Kazuo
Creators
Honma Takashi
Creators
Nakanishi Takashi
Creators
Utsumi Hiromoto
Creators
Yamada Norimasa
Source Identifiers
Hyperthemia induced 2450 MHz microwave was focused locally upon EATC tumor implanted in the foot of ICR mouse, when the tumor reached about 6mm in diameter. Normal skin reaction of the foot of the mouse on localized hyperthermia induced this apparatus was stronger than that on water bath, and so hyperthermia at 42℃ for 15 minutes was the maximum way for heating. Changes in regional blood flow volume of normal and tumor tissue following hyperthermia were observed by using^<133> Xe local clearance method. The blood flow of the tumor after heating by this apparatus decreased more remarkably than that on water bath, and decreased more than that of intact foot as heating temperature rose. Both of the stronger skin reaction and more decreased tumor blood flow, compared with the water bath, were seemed to suggest existence of the so-called hot spot effect. Hyperthermia induced by 2450 MHz microwave at 42℃ for 15 minutes delayed tumor growth (P<0.05) and showed a similar effect due to the water bath at 42℃ for 30 minutes. Enhancement of the local tumor control effect of X-ray-irradiation was also shown (P<0.01).
Languages
jpn
Resource Type
journal article
Publishers
山口大学医学会
Date Issued
1986-08
File Version
Not Applicable (or Unknown)
Access Rights
metadata only access
Relations
[ISSN]0513-1731
[NCID]AN00243156
Schools
医学部