The role of GABA-b receptor activity in central purinergic system in mice
山口医学 Volume 37 Issue 5
Page 389-394
published_at 1988-10
Title
GABA-bレセプター興奮の中枢プリン性機構への影響
The role of GABA-b receptor activity in central purinergic system in mice
Creators
Kaneyuki Hiroshi
Creators
Ushijima Itsuko
Creators
Mashimoto Shigeki
Creators
Obara Nami
Creators
Mizuki Yasushi
Creators
Yamada Michio
Source Identifiers
A behavioral study was performed in an attempt to clarify an interaction between the GABA-b and the adenosine A_1 receptors in aggressive behaviors induced by clonidine in mice. Mice administered high doses of clonidine (20-30mg/kg i.p.) exhibited aggressive behaviors such as biting and attacking. Baclofen (1-5mg/kg), a GABA-b receptor agonist, inhabited the aggressive behaviors induced by clonidine (20mg/kg) in dose-dependent manner. Caffeine (5-10mg/kg), an adenosine (A_1>A_2) receptor antagonist, markedly potentiated the aggressive behaviors. The inhibitory effect og baclofen (1mg/kg) on the aggressive behaviors induced by clonidine (20mg/kg) was antagonized by caffeine (5mg/kg). Furthermore the stimulatory effedt of caffeine (5mg/kg) was reversed by baclofen. Aminooxyacetic acid (AOAA : 30mg/kg), a GABA transaminase inhabitor, also reduced clonidine (30ng/kg) induced aggressive behaviors. The inhibitory effect of AOAA tended to be increaced by bicuculline (2mg/kg), a GABA-a receptor antagonist, but did not significantly. The inhibitory effect of combined treatment with AOAA and bicuculline on the aggressive behaviors was antagonized by caffeine (1mg/kg), whereas the stimulatory effect of caffeine on the behaviors was reversed by combined treatment with these drugs. The results suggest that since either baclofen (GABA-b receptor agonist) or AOAA (endogenous GABA) in hibits colonidine-induced aggressive behaviors which are potentiated by caffeine, an adenosine receptor antagonist, these agents may be, in part, similar to the mode of action of adenosine receptor agonist.
Languages
jpn
Resource Type
journal article
Publishers
山口大学医学会
Date Issued
1988-10
File Version
Not Applicable (or Unknown)
Access Rights
metadata only access
Relations
[ISSN]0513-1731
[NCID]AN00243156
Schools
医学部