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Serum Concentration of Oral Disopyramide in Eight Inpatients.

山口医学 Volume 35 Issue 1 Page 5-9
published_at 1986-02
Title
入院患者8名における内服disopyramideの血中濃度
Serum Concentration of Oral Disopyramide in Eight Inpatients.
Creators Sawa Akihiro
Creators Imamura Akihisa
Creators Suetomi Katsutoshi
Creators Koshiro Akira
Source Identifiers
Monitoring of serum concentration of disopyramide, one of the useful antiarrhythmiacs, has been recommended because of a slight difference between therapeutic serum level (2-5μg/ml) and toxic level (over 7μg/ml). Measurments of serum concentration by high performance liquid chromatography were carried out as regards eight inpatients with cardiovascular disease. These patients were administered disopyramide capsuls (Rythmodan^<【○!R】> 100mg/Cap.) orally over 2 weeks in our hospital. The dosage ranged from 1.6 to 3.0 mg/kg (the mean : 2.1mg/kg) and the results obtained were as follows. 1. The average of apparent distribution volume (Vd) was 0.98L/kg (ranged from 0.69 to 1.46L/kg). 2. The mean serum concentration of steady state (Css) determined as 3.11μg/ml. 3. The steady state concentrations in each patients were all within therapeutic level and it was found that the medications by disopyramide are performed adequately.
Subjects
医学 ( Other)
Languages jpn
Resource Type journal article
Publishers 山口大学医学会
Date Issued 1986-02
File Version Not Applicable (or Unknown)
Access Rights metadata only access
Relations
[ISSN]0513-1731
[NCID]AN00243156
Schools 医学部