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Two Cases of Hyperthyroidism Associated with Idiopathic Thrombocytopenic Purpura

山口医学 Volume 32 Issue 2 Page 217-222
published_at 1983-04
Title
甲状腺機能亢進症に特発性血小板減少性紫斑症を合併した2症例
Two Cases of Hyperthyroidism Associated with Idiopathic Thrombocytopenic Purpura
Creators Inoue Masamitsu
Creators Yamada Katsunori
Creators Matsumura Shigeichi
Creators Kaneko Toshio
Creators Matsumoto Noboru
Source Identifiers
Case 1 : A 27-year-old female was referred to our hospital because of hyperthyroidism and idiopathic thrombocytopenic purpura (ITP). Laboratory examination revealed marked thrombocytopenia (1,000/mm^3) and slightly increase of megakaryocytes in the bone marrow. Serum levels of T_3, T_4 and PBI were 265 ng/dl, 11μg/dl and 8.2μg/dl, respectively. She was treated with prednisolone and methimazole, and her good improvement was observed after correction of the thyroid function. Case 2 : A27-year-old female was referred to our hospital because of hyperthyroidism and ITP. She was treated with propylthiouracil for 2 years before admission. Laboratory examination revealed marked thrombocytopenia (7,000/mm^3), iron deficiency anemia (Hb 7.3g/dl) and increase of megakaryocytes in the bone marrow. Thyroid function was in euthyroid state on admission. (T_3 91ng/dl, T_4 9.7 μg/dl, PBI 6.5 μg/dl) Her platelets were effectively increased soon after prednisolone administration. She took only 50 mg of propylthiouracil after splenectomy, which induced remission of ITP. The incidence of hyperthyroidism with ITP (5.9%), or ITP with hyperthyroidism (0.7%) in our ward is very high compared with general incidence of each disease. The platelet counts returned to normal range after hyperthyroidism was well treated. The observation of these cases suggests that hyperthyroidism probably influences thrombocytopenia, and close relation between ITP and hyperthyroidism.
Subjects
医学 ( Other)
Languages jpn
Resource Type journal article
Publishers 山口大学医学会
Date Issued 1983-04
File Version Not Applicable (or Unknown)
Access Rights metadata only access
Relations
[ISSN]0513-1731
[NCID]AN00243156
Schools 医学部