On Trimethylsilylation of Methamphetamine and its Related Compounds and Method for Determination of the Derivatives
山口医学 Volume 32 Issue 6
Page 609-614
published_at 1983-12
Title
覚せい剤メタンフェタミンおよびその関連化合物のtrimethylsilyl誘導体の作成と定量について
On Trimethylsilylation of Methamphetamine and its Related Compounds and Method for Determination of the Derivatives
Creators
Sugawara Norisuke
Creators
Furuno Junji
Source Identifiers
Direct analysis of methamphetamine and its related compounds is usually diffieult by gas chromatography, because of the methylamino, amino, hydroxyl and carboxyl groups that react with the column supporter to form a hydrogen bonnd. In the study here, the specimens were first converted to trimethylsilyl derivatives by reaction with hexamethyldisilazane and trimethylchlorsilane, and these derivatives were submitted to gas chromatography. Compounds other than methamphetamine were successfully trimethylsilylated, and the calibration curves were depicted on the basis of the peak area or peak length ratio of each derivatives against the respective, corresponding internal standard. The resulting curves indicated linear relatioships.
Languages
jpn
Resource Type
journal article
Publishers
山口大学医学会
Date Issued
1983-12
File Version
Not Applicable (or Unknown)
Access Rights
metadata only access
Relations
[ISSN]0513-1731
[NCID]AN00243156
Schools
医学部