Clinical and Experimental Studies on Renal Damage in Liver Disease-the Role of Endotoxin in the Mechanism of its Development

肝疾患時における腎障害発生へのエンドトキシン関与に関する臨床的、実験的研究

Clinical and Experimental Studies on Renal Damage in Liver Disease-the Role of Endotoxin in the Mechanism of its Development

Creators Akagawa Etsuo

The present studies were were carried out to ascertain whether endotoxemia can be a possible cause of renal damage in various liver disease. 1) Clinical study : Endotoxin was measured by Limulus assay in peripheral blood from 106 patients with various liver disease. A positive test was obtained in 29 (27.4%). Incidence of endotoxemia was especially high in fulminant hepatitis （55.6%）, liver cirhosis (30.4%), and obstructive jaundice (32.0%). Endotoxemia correclated well with the level of serum total bilirubin and the presence of ascites. There was also a correlation between endotoxemia and serum NPN. Renal damage were more frequently associated with endotoxemia in patients with a relatively high serum total bilirubin level (more than 15 mg/dl) than in those with relatively low level (less than 5mg/dl).…

[ISSN]0513-1731

[NCID]AN00243156