Lymphoid Tissues in Radiation Chimeras

放射線キメラのリンパ組織

Lymphoid Tissues in Radiation Chimeras

Creators Kuniki Hiromichi

The purpose of this study is to analyse the mechanism of achievement and maintenance of radiation chimerism. Inbred DA and PVG/c strain rats were thymectomized when 4 to 6 weeks old. Four to 8 weeks later they were lethally irradiated with 800 to 1000 R and shortly thereafter injected intravenously with 5-15×10^8 viable bone marrow cells from (PVG/c×DA)F_1 hybrid. These rats were then grafted with (PVG/c×DA)F_1 hybrid skin (Fig. 1). 19 out of 23 DA and 20 out of 36 PVG/c rats protected with (PVG/c×DA)F_1 bone marrow cells survived for more than 60 days without rejecting the skin graft (Table 1). Such rats will be referred to as semiallogeneic radiation chimeras (Fig 3)…

[ISSN]0513-1731

[NCID]AN00243156