Effects of female hormone withdrawal and ulipristal acetate on MED12 mutation positive and negative uterine leiomyomas using a xenograft model.
Scientific reports Volume 15
published_at 2025-11-14
Supplemental Data : https://public.oa.kenkyu.yamaguchi-u.ac.jp/41aca251-9955-463e-9b47-ba073689ad15
Title
Effects of female hormone withdrawal and ulipristal acetate on MED12 mutation positive and negative uterine leiomyomas using a xenograft model.
Creators
Sakai Takahiro
Creators
Takasaki Hitomi
Source Identifiers
[EISSN] 2045-2322
Creator Keywords
Uterine leiomyomas
Xenograft models
Female hormones
Ulipristal acetate
MED12 mutation
Smooth muscle cells
Languages
eng
Resource Type
journal article
Publishers
Springer Nature
Date Issued
2025-11-14
Rights
Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International(https://creativecommons.org/licenses/by-nc-nd/4.0/)
© The Author(s) 2025()
File Version
Version of Record
Access Rights
open access
Relations
[isIdenticalTo]
10.1038/s41598-025-23721-5
[isSupplementedBy]
[URI]https://public.oa.kenkyu.yamaguchi-u.ac.jp/41aca251-9955-463e-9b47-ba073689ad15
Funding Refs
Japan Society for the Promotion of Science
[crossref_funder]https://doi.org/10.13039/501100001691
Award
Pathophysiology of uterine leiomyomas grown in a female hormone-independent manner using single-cell analysis
24K12533
Funding Refs
Japan Society for the Promotion of Science
[crossref_funder]https://doi.org/10.13039/501100001691
Award
Clarifying the ptathogenesis of decidualization failure using a novel human in vitro implantation model
24K12579
Funding Refs
Japan Society for the Promotion of Science
[crossref_funder]https://doi.org/10.13039/501100001691
Award
Heme oxygenase1発現抑制と三酸化二砒素を用いた子宮頸癌の新規治療法の開発
24K12626
Funding Refs
Japan Society for the Promotion of Science
[crossref_funder]https://doi.org/10.13039/501100001691
Award
独自の改良型子宮内膜オルガノイドを応用した着床機構および着床不全の病態の解明
23K27734
Funding Refs
Japan Society for the Promotion of Science
[crossref_funder]https://doi.org/10.13039/501100001691
Award
Study for the mechanisms of uterine fibroid development and its diversity from the view of microenvironment using single cell analysis
22K19603