Dynamic changes and importance of plasma concentrations of ether phospholipids, of which the majority are plasmalogens, in postpartum Holstein dairy cows
Reproduction, Fertility and Development
published_at 2023-07-19
2023-7-19-14-45Repository＿CLEAN Changes_of_plasmalogens_in_postpartum_dairy_cowsEditage20230528.pdf
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https://doi.org/10.1071/RD23057
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Title
Dynamic changes and importance of plasma concentrations of ether phospholipids, of which the majority are plasmalogens, in postpartum Holstein dairy cows
Abstract
Context: Ethanolamine plasmalogens (EPls) and choline plasmalogens (CPls) are classes of ethanolamine ether phospholipids (ePE) or choline ether phospholipids (ePC), respectively. EPls play crucial roles in maternal and breastfed infant bodies and stimulate gonadotropin secretion by gonadotrophs.
Aims: To estimate changes in and importance of plasma concentrations of EPls and CPls, utilizing newly developed enzymatic fluorometric assays for ePE and ePC in postpartum Holstein cows.
Methods: Plasma samples were collected 3 weeks before expected parturition until approximately 8 weeks after parturition (16 primiparous and 38 multiparous cows) for analysis.
Key results: Plasma concentrations of ePE and ePC, most of which are plasmalogens, declined before and increased after parturition and stabilised near the day of the first postpartum ovulation (1stOV). From weeks 2 to 3 after parturition, third-parity cows exhibited ePE concentrations that were higher than those of other parity cows. The days from parturition to 1stOV correlated with days from parturition to conception. On the day of 1stOV, milk yield correlated with plasma concentration of both ePE and ePC, while ePC concentration correlated negatively with milk fat percentage. At the early luteal phase after 1stOV, plasma ePE concentration correlated with plasma anti-Müllerian hormone concentration (r = 0.39, P < 0.01), and plasma ePC concentration correlated with plasma follicle-stimulating hormone concentration (r = 0.43, P < 0.01).
Conclusion: The concentrations of ePE and ePC changed dramatically around parturition and 1stOV, and then the concentrations correlated with the important parameters.
Implications: The blood plasmalogen may play important roles in postpartum dairy cows.
Aims: To estimate changes in and importance of plasma concentrations of EPls and CPls, utilizing newly developed enzymatic fluorometric assays for ePE and ePC in postpartum Holstein cows.
Methods: Plasma samples were collected 3 weeks before expected parturition until approximately 8 weeks after parturition (16 primiparous and 38 multiparous cows) for analysis.
Key results: Plasma concentrations of ePE and ePC, most of which are plasmalogens, declined before and increased after parturition and stabilised near the day of the first postpartum ovulation (1stOV). From weeks 2 to 3 after parturition, third-parity cows exhibited ePE concentrations that were higher than those of other parity cows. The days from parturition to 1stOV correlated with days from parturition to conception. On the day of 1stOV, milk yield correlated with plasma concentration of both ePE and ePC, while ePC concentration correlated negatively with milk fat percentage. At the early luteal phase after 1stOV, plasma ePE concentration correlated with plasma anti-Müllerian hormone concentration (r = 0.39, P < 0.01), and plasma ePC concentration correlated with plasma follicle-stimulating hormone concentration (r = 0.43, P < 0.01).
Conclusion: The concentrations of ePE and ePC changed dramatically around parturition and 1stOV, and then the concentrations correlated with the important parameters.
Implications: The blood plasmalogen may play important roles in postpartum dairy cows.
Creators
Saito Risa
Creators
Kubo Tomoaki
Creators
Wakatsuki Takuji
Creators
Tanigawa Tamako
Creators
Kotaniguchi Miyako
Creators
Hashimoto Maki
Creators
Kitamura Shinichi
Creators
Kadokawa Hiroya
[e_rad]80370592
Affiliate Master
Yamaguchi University
[kakenhi]15501
grid.268397.1
Source Identifiers
[PISSN] 1031-3613
[EISSN] 1448-5990
Creator Keywords
aging
anti-Müllerian hormone
choline plasmalogen
conception
ethanolamine plasmalogens
first postpartum ovulation
functional lipids
FSH
G protein-coupled receptor 61
GPR61
LH
parity
phospholipase A1
postpartum Holstein dairy cows
ruminant
Languages
eng
Resource Type
journal article
Publishers
CSIRO Publishing
Date Issued
2023-07-19
File Version
Accepted Manuscript
Access Rights
open access
Relations
[isVersionOf]
https://doi.org/10.1071/RD23057
Funding Refs
Japan Society for the Promotion of Science
[crossref_funder]https://doi.org/10.13039/501100001691
Award
ウシ視床下部で発見された泌乳・加齢による繁殖障害の原因物質：現場での応用に向けて
21H02345