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A case of Castleman's disease of hyaline-vascular type associated with pure red cell aplasia which was successfully treated with cyclosporine

The bulletin of the Yamaguchi Medical School Volume 56 Issue 1-2 Page 15-19
published_at 2009
A050056000103.pdf
[fulltext] 921 KB
Title
A case of Castleman's disease of hyaline-vascular type associated with pure red cell aplasia which was successfully treated with cyclosporine
Creators Suzukawa Munehiro
Creators Kondo Manabu
Creators Sugiyama Akiko
Creators Tominaga Takayuki
Creators Shinohara Kenji
Creators Kamei Toshiaki
Source Identifiers
Creator Keywords
Castleman's disease hyaline-vascular type pure red cell aplasia cyclosporine
A 70-year-old female complained of palpitation. CBC demonstated anemia and bone marrow aspiration smear demonstrated absence of erythroid hematopoietic cells, and pure red cell aplasia (PRCA) was diagnosed. Computed tomography (CT) demonstrated abdominal tumor. Biopsy of the abdominal tumor showed proliferation of lymph follicles with small and medium-sized lymphocytes, angiofollicular pattern in their center, and hyalinization around the surrounding tissue. Based on these findings, Castleman's disease (CD) of hyaline-vascular (HV) type was diagnosed. Since anemia progressed, a possible relation between the pathogenesis of PRCA and CD was considered. Therefore, prednisolone (PSL) was dministered for two months as well as two courses of COP (cyclophosphamide, oncovin and prednisolone) chemotherapy and 40Gy radiation to the abdominal tumor. After these treatments, the size of abdominal tumor decreased, but PRCA did not improve. Subsequently cyclosporine was administered for five months, and was effective for the improvement of anemia. These results indicated the immunological pathogenesis of PRCA even in Castleman's disease of hyaline-vascular type.
Languages eng
Resource Type departmental bulletin paper
Publishers Yamaguchi University School of Medicine
Date Issued 2009
File Version Version of Record
Access Rights open access
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